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KMID : 0545120090190121573
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 12 p.1573 ~ p.1575
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Reticulone, a novel free radical scavenger produced by Aspergillus sp.
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Ryoo In-Ja
Xu Guang-Hua
Kim Young-Hee
Choo Soo-Jin
Ahn Jong-Seog
Yoo Ick-Dong
Bae Ki-Hwan
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Abstract
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Bioassay-guided fractionation of the culture broth of Aspergillus sp. FN070449 (KCTC 26428) using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of two compound: reticulone (1) and reticulol (2). Their chemical structures were elucidated on the basis of UV, IR, NMR, and MS spectroscopic analysis. Compound 1 exhibited more potent free radical scavenging activity on ABTS.+ radicals and DPPH radicals than butylated hydroxyanisole(BHA) and caffeic acid.
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KEYWORD
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Aspergillus sp., reticulone, DPPH, ABTS
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